• Posted on: Mar 26, 2025
  • Location: Rockville, MD
  • Job ID: 6666d8b8
  • Type: Full Time
  • Category: Engineering
  • Posted on: Mar 26, 2025
  • Location: Rockville, MD
  • Job ID: 6666d8b8
  • Type: Full Time
  • Category: Engineering

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Molecular Diagnostics Engineer – Point-of-Care Technologies

 

Key Responsibilities: 

  1. Develop and Optimize Isothermal Amplification Technologies
    • Design, implement, and validate novel isothermal DNA amplification methods
    • Troubleshoot technical challenges in amplification efficiency and stability
  2. Engineer and Modify Enzymes for Diagnostic Applications
    • Create customized enzyme variants with improved performance characteristics
    • Establish robust protocols for enzyme production and quality control
  3. Design Advanced Molecular Detection Systems
    • Create innovative signal amplification and detection strategies
    • Integrate amplification chemistry with detection modalities
  4. Translate Laboratory Protocols to Point-of-Care Formats
    • Adapt complex molecular methods to simplified, field-deployable formats
    • Balance technical performance with usability requirements
  5. Lead Technical Innovation and Validation
    • Direct research efforts to address critical performance challenges
    • Collaborate with cross-functional teams to integrate technologies into product platforms
 

Experience:

 

  • Advanced Expertise in Isothermal Amplification Technologies
    • Demonstrated experience developing or optimizing isothermal amplification methods (LAMP, RPA, HDA, etc.)
    • Hands-on experience troubleshooting complex molecular diagnostic challenges
  • Enzyme Engineering and Characterization
    • Experience modifying DNA/RNA polymerases or other enzymes for improved performance
    • Demonstrable understanding of enzyme kinetics and biochemical optimization
    • Background in protein engineering or directed evolution methodologies
  • Point-of-Care Diagnostic Development
    • Knowledge of sample preparation challenges and solutions for complex biological matrices
    • Understanding of regulatory considerations for diagnostic development
  • Single-Molecule Detection Methods
    • Familiarity with nanopore technologies, fluorescence-based detection, or other single-molecule approaches
    • Experience integrating molecular amplification with detection modalities
    • Background in signal optimization and noise reduction strategies

 

Qualifications:

  • PhD in Molecular Biology, Biochemistry, Bioengineering, or related field
    • Strong academic foundation in nucleic acid biochemistry and molecular diagnostics
    • Research experience relevant to isothermal amplification technologies
  • Proven expertise in enzyme manipulation and optimization
    • Demonstrated ability to modify and enhance enzyme performance for specific applications
    • Understanding of structure-function relationships in nucleic acid processing enzymes
  • Publication record in molecular diagnostics or related fields
    • First-author publications demonstrating technical innovation
    • Evidence of contribution to advancement of diagnostic technologies
  • Laboratory proficiency with advanced molecular techniques
    • Mastery of nucleic acid extraction, amplification, and detection methodologies
    • Hands-on skill with relevant analytical instruments and techniques
  • Collaborative mindset with strong communication skills
    • Ability to work effectively with multidisciplinary teams
    • Experience translating complex technical concepts to diverse audiences
    • Track record of successful cross-functional project contributions

 

Additional Points:

 

— This is a full-time position with the potential title of Scientist, Senior Scientist, or Principal Scientist and the title is commensurate with experience and expertise.

— This role is based in Maryland, with a comprehensive relocation package available.

 

 

 

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