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Start up biotech company in Bay Area is seeking a Senior Scientist – Protein Engineer to design and build high-content protein libraries using rational engineering methodologies. This exciting new company is developing a proprietary technology platform to target various regenerative pathways critical for the establishment of complex diseases.
This exciting new company was founded in 2018 and is building the world’s leading platform for precision genetic regulation to address serious diseases with little to no available treatments. The technology platform works in a way that DNA does not need to be cut to accomplish precise gene regulation. This platform enables the design of medicines that flexibly, precisely and reversibly modify gene expression, a potential that drug developers have long sought to achieve but which today’s approaches fall short of accomplishing.

Requirements for the Senior Scientist – Protein Engineer:

  • PhD in molecular biology, genetics or related fields.
  • 2+ years industry or post-doc experience
  • A strong background in practical protein engineering, protein evolution, rational design methods, and an understanding of protein chemistry.
  • A solid understanding and experience in computational modeling of protein structure and domain analysis.
  • Prior experience setting up of high-throughput pipelines to functionally readout a large pool of protein variants, adoption of saturation mutagenesis strategy, or continuous directed evolution
  • A track record of accomplishment and publications in protein engineering
  • Creative mindset with a willingness to propose new approaches and ideas to improve the performance of specific proteins
  • Exceptional molecular biology skills (molecular cloning, DNA and RNA handling etc.
  • Background or knowledgable in DNA- and histone-binding proteins and their modifications preferred
  • CRISPR experience preferred
Responsibilities of the Senior Scientist – Protein Engineer:
  • Design and build high-content protein libraries using rational engineering methodologies

  • Use in vitro selection technologies to isolate proteins with desired properties

  • Optimize engineered proteins and antibodies through directed engineering efforts

  • Characterize engineered proteins in vivo biochemical assays

  • Develop screening assays (in vitro and in vivo) and selection methods for engineered protein variants

  • Document experiments and data

Occupational Category:19-1029. Biological Scientists, All Other

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Application Instructions: Please apply using the form or send your resume to Debbie Winkelbauer.
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