Principal Scientist, Peptide Bio-organic Chemistry

This BioPharma is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

Seeking a highly motivated and talented peptide chemistry leader to join our new discovery peptide research group. The successful candidate will work on the design, synthesis and characterization of novel peptides and peptide conjugates to discover next-generation peptide-based therapeutics. Your expert synthetic knowledge and proven design and synthetic accomplishments will enable you to have significant impact on Company’s projects. This is an exciting opportunity to grow your career and help discover peptide therapeutics of the future.

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Your Contributions (include, but are not limited to):

• Lead projects and teams towards agreed upon goals, ultimately working towards clinical candidate peptide nomination
• Design, synthesize and characterize peptides, small proteins and chemically-modified analogs using state-of-the-art synthesis, bioconjugation, purification, analytical and biophysical techniques
• Independent data-driven optimization of peptide SAR
• Effective communication of scientific rationale, results and interpretation at project, team and departmental meetings, contributing to strategic discussions.
• Active collaboration and sharing of expertise with colleagues
• Builds and enhances internal and external professional relationships
• Aid in recruiting of peptide group scientists
• Future management of more junior scientists

Requirements:

• PhD in organic chemistry, or related field, with at least 5 subsequent years of experience in the field
• Proficient in all aspects of modern peptide synthesis, bioconjugation, purification and analysis; capable of immediate independent laboratory work on solid- and solution-phase chemistry
• Strong publication record of accomplishment
• Strong understanding of peptide structure and associated biophysical techniques to assess peptide structure, stability and behavior in solution
• Experience in bioconjugation, time-extension and formulation strategies for peptides
• Excellent interpersonal skills with strong oral and written communication abilities
• Demonstration of cross-functional understanding related to drug development
• Assimilates data and research findings outside of Company for application to new scientific projects
• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools
• Ability to work as part of and lead teams
• Exhibits leadership skill and ability, typically leads lower levels and/or indirect teams
• Excellent computer, communications, problem-solving, and analytical thinking skills
• Sees broader picture, impact on multiple programs, teams and/or departments
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency